期刊
FOOD CHEMISTRY
卷 326, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2020.126987
关键词
Supramolecular solvent (SUPRAS); Dispersive solid phase extraction (dSPE); LC-MS/MS; Ionophore coccidiostats; Food analysis
资金
- Youth Employment Initiative
- Juan de la Cierva - Formacion
- Ramon y Cajal
- MINECO [CTQ2017-83823-R]
A single-step sample treatment, for the simultaneous extraction and clean-up for the determination of ionophore coccidiostats in EU legislated foodstuffs, is here proposed. The treatment is based on the combination of: (i) a supramolecular solvent with restricted access properties (SUPRAS-RAM), spontaneously formed by the addition of hexanol, water and THF to the sample; and (ii) dispersive solid phase extraction (dSPE). The SUPRAS-RAM extract was directly compatible with LC-MS/MS and no further re-extraction, evaporation or cleanup procedures were necessary. SUPRAS-RAM efficiently extracted the ionophores (recoveries in milk, eggs, fat, liver, kidney, and chicken and beef muscle were in the range 71-112%) and removed proteins and carbohydrates, whereas dSPE removed fats and other lipophilic compounds. The method was validated following the European Commission Decision 2002/657/EC. Detection limits (0.004-0.07 mu g kg(-1)) were far below the maximum residue limits (1-150 mu g kg(-1)). Method analytical and operational characteristics were suitable for routine determination of ionophores.
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