期刊
FITOTERAPIA
卷 146, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.fitote.2020.104682
关键词
Diels-Alder adducts; Morus alba; Morusalisin; PTP1B inhibitory activity
资金
- Drug Innovation Major Project [2018ZX09711001-001-001]
- Key Project at Central Government Level for the Ability Establishment of Sustainable Use for Valuable Chinese Medicine Resources [2060302]
- CAMS Innovation Fund for Medical Sciences [CIFMS-2017-I2M-3-013]
Six new Diels-Alder type adducts, morusalisins A-F (1-6), were isolated from Morus alba cell cultures. The structures of 1-6 were determined by extensive spectroscopic data analysis, including HRESIMS, NMR, and ECD experiments. Furthermore, compounds 1-6 exhibited potent protein tyrosine phosphatase 1B (PTP1B) inhibitory activity with IC50 values ranging from 1.14 to 2.24 mu M, making them promising as bioactive compounds for antidiabetic drug discovery.
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