期刊
FITOTERAPIA
卷 145, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.fitote.2020.104610
关键词
Persicaria maculosa; Flavanones; Chalcones; Stilbene; Diarylheptanoids; Cytotoxicity
资金
- Economic Development and Innovation Operative Program [GINOP-2.3.2-15-2016-00012, GINOP-2.3.2-15-2016-00020]
- Ministry of Human Capacities, Hungary [20391-3/2018/FEKUSTRAT]
- NKFIH [PD-121130, FK-124114]
- UEFISCDI [PN-III-P11.1-TE-2016-1352]
- [BO/00213/19/8]
- [UNKP-19-4SZTE-18]
Persicaria maculosa (Polygonaceae) has been used as edible and as medicinal plant since ancient times. As a result of multistep chromatographic purifications, chalcones [2'-hydroxy-3',4',6'-trimethoxychalcone (1), pashanone (2), pinostrobin chalcone (3)], flavanones [6-hydroxy-5,7-dimethoxyflavanone (4), pinostrobin (5), onysilin (6), 5-hydroxy-7,8-dimethoxyflavanone (7)], flavonol [3-O-methylgalangin (8)], stilbene [persilben (9)], diarylheptanoids [1,7-diphenylhept-4-en-3-one (10), dihydroyashabushiketol (12), yashabushidiol B (13)] and 3oxo-alpha-ionol-glucoside (11) were isolated from P. maculosa. The present paper reports for the first time the occurrence of diarylheptanoid-type constituents in the family Polygonaceae. Cytotoxicity of 1-5, 7 and 9-11 on 4 T1 mouse triple negative breast cancer cells was assayed by MTT test. None of the tested compounds reduced the cell viability to less than 80% of the control. On non-tumorigenic D3 human brain endothelial cells the decrease of cell viability was observed in case of 1 and 2. Further impedance measurements on 4 T1 and D3 cells a concentration-dependent decrease in the cell index of both cell types was demonstrated for 1, while 2 proved to be toxic only on endothelial cells.
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