期刊
FEBS JOURNAL
卷 288, 期 9, 页码 2856-2869出版社
WILEY
DOI: 10.1111/febs.15569
关键词
integrated stress response; mitochondrial dysfunction; mitochondrial protein biogenesis; mitochondrial proteostasis
资金
- Deutsche Forschungsgemeinschaft (DFG) under Germany's Excellence Strategy [CIBSS - EXC-2189, 390939984, SFB 1381, 403222702]
- Emmy Noether Programme
- Projekt DEAL
Mitochondrial protein homeostasis is crucial for cellular health and is maintained by a network of mitochondrial chaperones and proteases. When proteomic imbalances or defects in mitochondrial functions occur, protective cellular responses are activated to restore organellar integrity. This viewpoint discusses current knowledge of protective pathways in mitochondrial stress responses and addresses open questions in the field.
Mitochondrial protein homeostasis is crucial for cellular health, and perturbations have been linked to a plethora of human diseases. Proteostasis is maintained mainly by a network of mitochondrial chaperones and proteases, that assist in protein folding and degrade nonfunctional or superfluous proteins. Upon proteomic imbalances or defects in mitochondrial functions, protective cellular responses are activated to restore and maintain organellar integrity. This viewpoint describes our current knowledge and understanding of these protective pathways and addresses open questions and perspectives in the field of mitochondrial stress responses.
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