期刊
EXPERIMENTAL MECHANICS
卷 61, 期 1, 页码 191-201出版社
SPRINGER
DOI: 10.1007/s11340-020-00664-8
关键词
Left ventricular mechanics; Residual stress; Cardiac mechanics; Extracellular matrix
资金
- NSF CMMI GRANT [1933768]
- NIH [P01HL070687]
- Div Of Civil, Mechanical, & Manufact Inn
- Directorate For Engineering [1933768] Funding Source: National Science Foundation
This study investigated the contributions of collagen fiber network and myocytes to myocardial residual stress/strain in hypertensive rats fed with high-fat diet. The results showed that hypertension leads to reduced residual stress/strain in male and female rats, with collagen remaining the largest contributor, and sex-specific remodeling features were identified in both hypertensive and normotensive animals.
Background Hypertension drives myocardial remodeling, leading to changes in structure, composition and mechanical behavior, including residual stress, which are linked to heart disease progression in a gender-specific manner. Emerging therapies are also targeting constituent-specific pathological features. All previous studies, however, have characterized remodeling in the intact tissue, rather than isolated tissue constituents, and did not include sex as a biological variable. Objective In this study we first identified the contribution of collagen fiber network and myocytes to the myocardial residual stress/strain in Dahl-Salt sensitive rats fed with high fat diet. Then, we quantified the effect of hypertension on the remodeling of the left ventricle (LV), as well as the existence of sex-specific remodeling features. Methods We performed mechanical tests (opening angle, ring-test) and histological analysis on isolated constituents and intact tissue of the LV. Based on the measurements from the tests, we performed a stress analysis to evaluate the residual stress distribution. Statistical analysis was performed to identify the effects of constituent isolation, elevated blood pressure, and sex of the animal on the experimental measurements and modeling results. Results Hypertension leads to reduced residual stress/strain in the intact tissue, isolated collagen fibers, and isolated myocytes in male and female rats. Collagen remains the largest contributor to myocardial residual stress in both normotensive and hypertensive animals. We identified sex-differences in both hypertensive and normotensive animals. Conclusions We observed both constituent- and sex-specific remodeling features in the LV of an animal model of hypertension.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据