期刊
EUROSURVEILLANCE
卷 25, 期 42, 页码 33-41出版社
EUR CENTRE DIS PREVENTION & CONTROL
DOI: 10.2807/1560-7917.ES.2020.25.42.2000685
关键词
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资金
- Georg and Emily Opel Foundation
- Medical Research Council [MC_ PC_19059, MR/L006588/1]
- National Institute for Health Research Biomedical Research Centre Funding Scheme
- Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Science (CIFMS), China [2018-I2M-2-002]
- Schmidt Foundation
- Wellcome Trust [095541/A/11/Z, WT109965/MA]
- WTIA Grant [WT104748MA]
- ERC research grant `UNIFLUVAC'
- MRC CiC grants [BR00140]
- CRUK Cancer Immunology Award [C30332/A23521]
- Professor RW Snow's Wellcome Trust Principal Fellowship [212176]
- NIHR Research Capability Funding grant
- University of Oxford [NIHR200907]
- NIHR Biomedical Research Centre, Oxford
- MRC [MC_PC_19025, MR/V033441/1] Funding Source: UKRI
- UKRI [MR/S032304/1] Funding Source: UKRI
Background: The progression and geographical distribution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the United Kingdom (UK) and elsewhere is unknown because typically only symptomatic individuals are diagnosed. We performed a serological study of blood donors in Scotland in the spring of 2020 to detect neutralising antibodies to SARS-CoV-2 as a marker of past infection and epidemic progression. Aim: Our objective was to determine if sera from blood bank donors can be used to track the emergence and progression of the SARS-CoV-2 epidemic. Methods: A pseudotyped SARS-CoV-2 virus microneutralisation assay was used to detect neutralising antibodies to SARS-CoV-2. The study comprised samples from 3,500 blood donors collected in Scotland between 17 March and 18 May 2020. Controls were collected from loo donors in Scotland during 2019. Results: All samples collected on 17 March 2020 (n=500) were negative in the pseudotyped SARS-CoV-2 virus microneutralisation assay. Neutralising antibodies were detected in six of 500 donors from 23 to 26 March. The number of samples containing neutralising antibodies did not significantly rise after 5-6 April until the end of the study on 18 May. We found that infections were concentrated in certain postcodes, indicating that outbreaks of infection were extremely localised. In contrast, other areas remained comparatively untouched by the epidemic. Conclusion: Although blood donors are not representative of the overall population, we demonstrated that serosurveys of blood banks can serve as a useful tool for tracking the emergence and progression of an epidemic such as the SARS-CoV-2 outbreak.
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