期刊
EUROPEAN JOURNAL OF NUTRITION
卷 60, 期 4, 页码 2111-2120出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00394-020-02397-9
关键词
Olive leaf extract; Overweight; Cardiovascular disease; Blood lipid profiles
资金
- BioActor BV, Maastricht, The Netherlands
The purpose of this study was to investigate the effect of olive leaf extract (OLE) on blood lipid profiles in overweight/obese subjects with mildly elevated cholesterol levels. The results showed that 8 weeks of OLE supplementation did not significantly affect blood lipid levels, oxidized low-density lipoprotein, blood pressure, glucose, insulin levels, or liver function parameters.
Purpose Overweight and obesity are associated with many health problems, including cardiovascular disease (CVD). Evidence from previous studies has shown that extracts from olive leaves rich in olive phenolics are able to positively affect CVD risk factors, such as high blood pressure and dyslipidemia. The aim of this study was to investigate the effect of 8-week olive leaf extract (OLE) administration on blood lipid profiles in overweight/obese subjects with mildly elevated cholesterol levels. Methods In this randomized, double-blind, placebo-controlled study, 77 healthy adult overweight/obese subjects (aged 56 +/- 10 years and BMI 29.0 +/- 2.7 kg/m(2)) with total cholesterol levels of 5.0-8.0 mmol/L (5.9 +/- 0.7 mmol/L) were randomly assigned to receive 500 mg of OLE (n = 39) or placebo (n = 38) for 8 weeks. In total, 74 subjects completed the entire study protocol. At baseline, after 4 weeks, and after 8 weeks of supplementation, blood lipid profiles, oxidized low-density lipoprotein (oxLDL), blood pressure, glucose, and insulin levels were assessed. In addition, liver function parameters were measured at baseline and after 8 weeks. Results OLE supplementation did not significantly affect blood lipid levels after 4 weeks or after 8 weeks compared to placebo (allp > 0.05). For oxLDL, blood pressure, glucose, and insulin levels and liver function parameters, also no statistically significant differences were found between the two intervention groups (allp > 0.05). Conclusions Blood lipid profiles were not significantly affected by 8 weeks OLE supplementation in overweight/obese subjects with mildly elevated cholesterol levels. Trial registered The trial has been registered at ClinicalTrials.gov (NCT02990637).
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