Phase-amplitude coupling profiles differ in frontal and auditory cortices of bats

Neural oscillations are at the core of important computations in the mammalian brain. Interactions between oscillatory activities in different frequency bands, such as delta (1-4 Hz), theta (4-8 Hz) or gamma (>30 Hz), are a powerful mechanism for binding fundamentally distinct spatiotemporal scales of neural processing. Phase-amplitude coupling (PAC) is one such plausible and well-described interaction, but much is yet to be uncovered regarding how PAC dynamics contribute to sensory representations. In particular, although PAC appears to have a major role in audition, the characteristics of coupling profiles in sensory and integration (i.e. frontal) cortical areas remain obscure. Here, we address this question by studying PAC dynamics in the frontal-auditory field (FAF; an auditory area in the bat frontal cortex) and the auditory cortex (AC) of the batCarollia perspicillata. By means of simultaneous electrophysiological recordings in frontal and auditory cortices examining local-field potentials (LFPs), we show that the amplitude of gamma-band activity couples with the phase of low-frequency LFPs in both structures. Our results demonstrate that the coupling in FAF occurs most prominently in delta/high-gamma frequencies (1-4/75-100 Hz), whereas in the AC the coupling is strongest in the delta-theta/low-gamma (2-8/25-55 Hz) range. We argue that distinct PAC profiles may represent different mechanisms for neuronal processing in frontal and auditory cortices, and might complement oscillatory interactions for sensory processing in the frontal-auditory cortex network.

Automated summary

Neural oscillations play a central role in important computations in the mammalian brain. The interaction between oscillatory activities in different frequency bands is a powerful mechanism for binding different spatiotemporal scales in neural processing. Phase-amplitude coupling (PAC) is a well-known interaction, but its contribution to sensory representations is still not fully understood. This study investigates PAC dynamics in the frontal-auditory field (FAF) and the auditory cortex (AC) of bats, and reveals distinct PAC profiles in these areas. The findings suggest that different PAC profiles may represent different mechanisms for neuronal processing in frontal and auditory cortices.