期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 203, 期 -, 页码 -出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2020.112627
关键词
Ginsenoside Rh2; Anticancer; Mechanisms; Panax ginseng; Chemotherapy; Derivatives
资金
- Project of NDRC
- State Administration of Traditional Chinese Medicine [ZYBZH-Y-HUN-24]
- Hunan University of Chinese Medicine First-class Disciple Construction Project [201803]
- Hunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces [2016TP2008]
- Open found of Hunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces [BG201701]
Ginseng has been used as a well-known traditional Chinese medicine since ancient times. Ginsenosides as its main active constituents possess a broad scope of pharmacological properties including stimulating immune function, enhancing cardiovascular health, increasing resistance to stress, improving memory and learning, developing social functioning and mental health in normal persons, and chemotherapy. Ginsenoside Rh2 (Rh2) is one of the major bioactive ginsenosides from Panax ginseng. When applied to cancer treatment, Rh2 not only exhibits the anti-proliferation, anti-invasion, anti-metastasis, induction of cell cycle arrest, promotion of differentiation, and reversal of multi-drug resistance activities against multiple tumor cells, but also alleviates the side effects after chemotherapy or radiotherapy. In the past decades, nearly 200 studies on Rh2 in the treatment of cancer have been published, however no specific reviews have been conducted by now. So the purpose of this review is to provide a systematic summary and analysis of the anticancer effects and the potential mechanisms of Rh2 extracted from Ginseng then give a future prospects about it. In the end of this paper the metabolism and derivatives of Rh2 also have been documented. (C) 2020 Elsevier Masson SAS. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据