期刊
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷 201, 期 -, 页码 -出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2020.112510
关键词
beta-Lactam; Molecular hybridization approach; Structure activity relationship; Anticancer mechanisms
资金
- State Key Laboratory of Innovative Natural Medicine and TCM Injections [QFSKL2018001]
- Fundamental Research Funds for the Central Universities [2019-JYB-XS-062]
beta-Lactam, commonly referred as azetidin-2-one, is a multifunctional building block for synthesizing beta-amino ketones, gamma-amino alcohols, and other compounds. Besides its well known antibiotic activity, this ring system exhibits a wide range of activities, attracting the attention of researchers. However, the structurally diverse beta-lactam analogues as anticancer agents and their different molecular targets are poorly discussed. The purpose of this review is 3-fold: (1) to explore the molecular hybridization approach to design beta-lactams hybrids as anticancer agents; (2) the structure activity relationship of the most active anticancer beta-lactams and (3) to summarize their antitumor mechanisms. (C) 2020 Elsevier Masson SAS. All rights reserved.
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