期刊
EPIGENETICS
卷 16, 期 5, 页码 469-487出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15592294.2020.1809873
关键词
MLL; SETD1A; non-canonical functions; cell cycle; non-histone protein substrates
资金
- DBT/Wellcome Trust India Alliance [IA/S/18/2/503981]
- Department of Biotechnology (DBT), Government of India [BT/PR13351/BRB/10/1403/2015]
- Department of Science and Technology, Government of India [EMR/2016/000406]
The SET1 family of enzymes are well known for their involvement in histone 3 lysine 4 methylation, with distinct biological functions and implications if impaired. Recent studies have shown novel non-canonical functions of these enzymes beyond H3K4 methylation, highlighting their importance in cellular functions.
The SET1 family of enzymes are well known for their involvement in the histone 3 lysine 4 (H3K4) methylation, a conserved trait of euchromatin associated with transcriptional activation. These methyltransferases are distinct, and involved in various biological functions in the cell. Impairment in the function of SET1 family members leads to a number of abnormalities such as skeletal and neurological defects, leukaemogenesis and even lethality. Tremendous progress has been made in understanding the unique biological roles and the mechanism of SET1 enzymes in context with H3K4 methylation/canonical functions. However, in recent years, several studies have indicated the novel role of SET1 family proteins, other than H3K4 methylation, which are equally important for cellular functions. In this review, we focus on these non-canonical function of SET1 family members.
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