The m6A epitranscriptome opens a new charter in immune system logic

N6-methyladenosine (m6A), the most prevalent RNA internal modification, is present in most eukaryotic species and prokaryotes. Studies have highlighted an intricate network architecture by which m6A epitranscriptome impacts on immune response and function. However, it was only until recently that the mechanisms underlying the involvement of m6A modification in immune system were uncovered. Here, we systematically review the m6A involvement in the regulation of innate and adaptive immune cells. Further, the interplay between m6A modification and anti-inflammatory, anti-viral and anti-tumour immunity is also comprehensively summarized. Finally, we focus on the future prospects of m6A modification in immune modulation. A better understanding of the crosstalk between m6A modification and immune system is of great significance to reveal new pathogenic pathways and to develop promising therapeutic targets of diseases.

Automated summary

This review systematically examines the role of m6A modification in regulating immune cells and its implications in anti-inflammatory, anti-viral, and anti-tumour immunity. Understanding the crosstalk between m6A modification and the immune system is crucial for uncovering new pathogenic pathways and developing promising therapeutic targets for diseases.