期刊
ENVIRONMENTAL RESEARCH
卷 195, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.envres.2020.110317
关键词
Coronavirus; SARS-CoV-2; COVID-19; ACE2; TMPRSS2; FURIN; Cathepsin genes; Environmental exposure
资金
- French Government through its Investments for the Future program [ANR-11-LABX0071, ANR-18-IDEX-0001]
- Fondation pour la Recherche Medicale [AJE20151234749]
- Labex Who am I? [ANR-11-LABX-0071, ANR11-IDEX-005-02, ANR-11LABX-0071]
- CNRS
- INSERM
- University of Paris
- French Government
This study identified more than 50 chemicals that may regulate key genes involved in cellular entry of the novel coronavirus SARS-CoV-2. The findings suggest that environmental exposures could influence the expression of these genes, potentially impacting our understanding of COVID-19 disease.
The role of environmental condition on the infection by the novel pathogenic SARS-CoV-2 virus remains uncertain. In here, exploiting a large panel of publicly available genome-wide data, we investigated whether the human receptor ACE2 and human proteases TMPRSS2, FURIN and CATHEPSINs (B, L and V), which are involved in SARS-CoV-2 cell entry, are transcriptionally regulated by environmental cues. We report that more than 50 chemicals modulate the expression of ACE2 or human proteases important for SARS-CoV-2 cell entry. We further demonstrate that transcription factor AhR, which is commonly activated by pollutants, binds to the promoter of TMPRSS2 and enhancers and/or promoters of Cathepsin B, L and V encoding genes. Our exploratory study documents an influence of environmental exposures on the expression of genes involved in SARS-CoV-2 cell entry. These results could be conceptually and medically relevant to our understanding of the COVID-19 disease, and should be further explored in laboratory and epidemiologic studies.
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