期刊
ELECTROPHORESIS
卷 42, 期 1-2, 页码 19-37出版社
WILEY
DOI: 10.1002/elps.202000185
关键词
Capillary electrophoresis; Drug degradation; Drug impurity; Electrokinetic chromatography; Enantioseparation
资金
- Institute of Analytical Chemistry, Czech Academy of Sciences in Brno, Czech Republic [RVO 68081715]
- Ministry of Education, Youth and Sport of the Czech Republic [MTB 8F17003]
This review summarizes capillary electrophoretic methods suitable for routine quality control analyses of small molecule drugs published since 2015, discussing key parameters of over 80 methods and the contributions of reported results to separation science and practical applications.
Capillary electrophoresis represents a promising technique in the field of pharmaceutical analysis. The presented review provides a summary of capillary electrophoretic methods suitable for routine quality control analyses of small molecule drugs published since 2015. In total, more than 80 discussed methods are sorted into three main sections according to the applied electroseparation modes (capillary zone electrophoresis, electrokinetic chromatography, and micellar, microemulsion, and liposome-electrokinetic chromatography) and further subsections according to the applied detection techniques (UV, capacitively coupled contactless conductivity detection, and mass spectrometry). Key parameters of the procedures are summarized in four concise tables. The presented applications cover analyses of active pharmaceutical ingredients and their related substances such as degradation products or enantiomeric impurities. The contribution of reported results to the current knowledge of separation science and general aspects of the practical applications of capillary electrophoretic methods are also discussed.
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