期刊
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING
卷 19, 期 12, 页码 1347-1358出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10255842.2016.1140748
关键词
Actin stress fiber remodeling; ODE system with periodic coefficients; analytical approximation; cyclic strain
资金
- European Union
- REA [317512]
Understanding collagen and stress fiber remodeling is essential for the development of engineered tissues with good functionality. These processes are complex, highly interrelated, and occur over different time scales. As a result, excessive computational costs are required to computationally predict the final organization of these fibers in response to dynamic mechanical conditions. In this study, an analytical approximation of a stress fiber remodeling evolution law was derived. A comparison of the developed technique with the direct numerical integration of the evolution law showed relatively small differences in results, and the proposed method is one to two orders of magnitude faster.
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