期刊
DRUG DEVELOPMENT RESEARCH
卷 82, 期 2, 页码 241-250出版社
WILEY
DOI: 10.1002/ddr.21747
关键词
antibiotic release; chitosan-gelatin hydrogels; hyaluronic acid nanoparticles embedding
资金
- Hitit University Scientific and Technical Application and Research Center
The study introduced the development of chitosan-gelatin hydrogels embedded with ampicillin-loaded hyaluronic acid nanoparticles for wound dressing, demonstrating their antibacterial properties and low cytotoxicity, indicating potential as a controlled drug delivery system.
The development of chitosan-gelatin (CS-G) hydrogels embedded with ampicillin-loaded hyaluronic acid nanoparticles (HA-NPs) for wound dressing is proposed. It was aimed to provide controlled ampicillin delivery by incorporation of HA-NPs into biocompatible CS-G hydrogel structure. According to in vitro ampicillin release studies, 55% of ampicillin was released from CS-G/HA-NPs hydrogels after 5 days. Antibacterial performance of CS-G/HA-NPs hydrogels was proven with agar disc diffusion test. For cytotoxicity assay, fibroblast cell viability increased in CS-G/HA-NPs hydrogels compared with CS-G group after 24 hr incubation. Consequently, the potential ability of CS-G/HA-NPs hydrogels as a controlled drug delivery system has been verified.
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