期刊
DEVELOPMENTAL PSYCHOBIOLOGY
卷 63, 期 3, 页码 496-511出版社
WILEY
DOI: 10.1002/dev.22037
关键词
developmental changes; immune activation; lipopolysaccharide; maturation; risk-taking; stress
资金
- Natural Sciences and Engineering Research Council of Canada
The study found that adolescent rats are more likely to display risky locomotor and anxiety-like behaviors compared to adult rats, with females showing more of these behaviors than males. However, being injected with LPS twice in early adolescence did not have a significant impact on these behaviors.
Risk-taking behaviors are a primary contributor to elevated adolescent injury and mortality. Locomotor and anxiety-like behaviors in rodents have been used to examine risk-taking. Here, we examined risk-taking behavior (i.e., changes in locomotor and anxiety-like behaviors) from early to late adolescence and adulthood in male and female rats in the open-field (OF) apparatus and the light-dark (LD) test. We also examined whether these behaviors are affected by an early adolescent immune stressor, lipopolysaccharide (LPS). Long-Evans male and female rats were injected with LPS (200 mu g/kg) or vehicle control in early adolescence (postnatal day [PND] 30 and 32). Anxiety-like behavior and locomotor activity were measured in early (PND 38-40), late adolescence (PND 50), and adulthood (PND 88 and 98) in the OF and in early adolescence (PND 42) and adulthood (PND 90) in the LD test. Early and late adolescent rats displayed significantly greater locomotor and anxiety-like behaviors than adult rats in the OF and LD test. Sex differences were also found, with adolescent and adult females displaying greater locomotor and anxiety-like behaviors than male rats in the OF and LD tests. LPS administered two times in early adolescence did not have a significant impact on either locomotor or anxiety-like behaviors suggesting minimal impact of the immune stressor.
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