期刊
DEVELOPMENTAL CELL
卷 55, 期 2, 页码 195-+出版社
CELL PRESS
DOI: 10.1016/j.devcel.2020.09.001
关键词
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资金
- Medical Research Council UK (MRC Program) [MC_UU_12018/5]
- European Research Council [311637-MorphoCorDiv, 820188-NanoMechShape]
- Leverhulme Trust (Leverhulme Prize in Biological Sciences)
- Royal Society (Royal Society Research Fellowship)
- EMBO [ALTF 2015563]
- Wellcome Trust [201334/Z/16/Z]
- Fondation BettencourtSchueller
- Wellcome Trust [201334/Z/16/Z] Funding Source: Wellcome Trust
- MRC [MC_UU_00012/5, MC_PC_17230, MC_UU_12018/5] Funding Source: UKRI
Cell fate transitions are key to development and homeostasis. It is thus essential to understand the cellular mechanisms controlling fate transitions. Cell division has been implicated in fate decisions in many stem cell types, including neuronal and epithelial progenitors. In other stem cells, such as embryonic stem (ES) cells, the role of division remains unclear. Here, we show that exit from naive pluripotency in mouse ES cells generally occurs after a division. We further show that exit timing is strongly correlated between sister cells, which remain connected by cytoplasmic bridges long after division, and that bridge abscission progressively accelerates as cells exit naive pluripotency. Finally, interfering with abscission impairs naive pluripotency exit, and artificially inducing abscission accelerates it. Altogether, our data indicate that a switch in the division machinery leading to faster abscission regulates pluripotency exit. Our study identifies abscission as a key cellular process coupling cell division to fate transitions.
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