期刊
DEVELOPMENT
卷 147, 期 19, 页码 -出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.161430
关键词
Gene regulation; Development; Nucleus; Transcription factors; Transcriptional microenvironment
资金
- Deutsche Forschungsgemeinschaft [TS 428/1-1]
- European Molecular Biology Laboratory Interdisciplinary Postdoc Programme (EIPOD) under Marie Sklodowska-Curie Actions COFUND [664726]
- European Molecular Biology Laboratory (EMBL)
Developmental enhancers drive gene expression in specific cell types during animal development. They integrate signals from many different sources mediated through the binding of transcription factors, producing specific responses in gene expression. Transcription factors often bind low-affinity sequences for only short durations. How brief, low-affinity interactions drive efficient transcription and robust gene expression is a central question in developmental biology. Localized high concentrations of transcription factors have been suggested as a possible mechanism by which to use these enhancer sites effectively. Here, we discuss the evidence for such transcriptional microenvironments, mechanisms for their formation and the biological consequences of such sub-nuclear compartmentalization for developmental decisions and evolution.
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