期刊
CYTOKINE
卷 147, 期 -, 页码 -出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.cyto.2020.155248
关键词
NLRP3 inflammasome; IL-1 beta; IL-18; Cutaneous leishmaniasis; Murine CL; Human CL
资金
- Moroccan Ministry of National Education, Professional Training, Higher Education and Scientific Research (CNRST) [PPR/2015/27]
Cutaneous leishmaniasis is a vector-borne parasitic disease caused by the Protozoa of the genus Leishmania, with its pathology influenced by the host's genetic background and immune status. The NLRP3 inflammasome appears to play a role in the disease's pathophysiology, although current studies show contradictory effects on the evolution of Leishmania infection in mice and humans.
Cutaneous leishmaniasis (CL) is a vector-borne parasitic disease caused by Protozoa of the genus Leishmania. Clinical manifestations of this disease are the result of a complex interplay of diverse factors, including the genetic background and the immune status of the host. Understanding the impact of these factors on the CL pathology may provide new targets to manage the infection and improve clinical outcome. The NLRP3 inflammasome, an innate immune complex of several cell types, seems to be involved in the CL physiopathology. Current studies of its role show contradictory effects of this complex on the evolution of Leishmania infection in mice and humans. In this review, we discuss the data regarding different roles of the NLRP3 inflammasome in murine and human CL.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据