期刊
CYTOKINE
卷 133, 期 -, 页码 -出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.cyto.2020.155121
关键词
Macrophage migration inhibitory factor; MIF; DDT; D-dopachrome tautomerase; CD74
资金
- Support Program for Research Projects and Technological Innovation UNAM-DGAPA-PAPIIT [IN-209718]
- National Council of Science and Technology of Mexico (CONACYT) [A1-S-10463]
- Programa de Becas Posdoctorales DGAPA-UNAM
- CONACYT [694650]
Human macrophage migration inhibition factor (MIF) is a protein with cytokine and chemokine properties that regulates a diverse range of physiological functions related to innate immunity and inflammation. Most research has focused on the role of MIF in different inflammatory diseases. D-dopachrome tautomerase (DDT), a different molecule with structural similarities to MIF, which shares receptors and biological functions, has recently been reported, but little is known about its roles and mechanisms. In this review, we sought to understand the similarities and differences between these molecules by summarizing what is known about their different structures, receptors and mechanisms regulating their expression and biological activities with an emphasis on immunological aspects.
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