Recent Advances in On-Water Multicomponent Synthesis of Coumarin Derivatives

Coumarin-linked heterocycles represent privileged structural subunits and are well-distributed in naturally occurring compounds with immense biological activities. Multicomponent reactions (MCRs) arc becoming a valuable tool for synthesizing structurally diverse molecular entities. On the other hand, the last year has seen a tremendous outburst in modifybig chemical processes to make them sustainable for the betterment of our environment. The application of aqueous medium in organic synthesis is fulfilling some of the goals of 'green and sustainable chemistry' as it has some advantages over the traditional synthetic methods in terms of reaction rates, yields, purity of the products, product selectivity, etc. Hence, significant progress has been made in recent years. To the present review, we provide an overview of the recent developments of multicomponent synthesis of biologically relevant couniarin linked and fused heterocyclic compounds carried out from 2015 till today in an aqueous medium.