期刊
CURRENT OPINION IN RHEUMATOLOGY
卷 32, 期 6, 页码 583-589出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/BOR.0000000000000739
关键词
B cell; cutaneous lupus erythematosus; neutrophil; plasmacytoid dendritic cell; systemic lupus erythematosus; T cell
类别
资金
- National Institutes of Health [T32-GM007863]
- National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health [R01-AR071384, K24-AR-076975-01, P30-AR075043]
- Lupus Research Alliance
- Doris Duke Charitable Foundation
- Rheumatology Research Foundation
- A. Alfred Taubman Medical Research Institute
- Parfet Emerging Scholar Award
Purpose of review Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with multiple manifestations, with a majority of SLE patients having cutaneous involvement. Despite ongoing research, the relationship between SLE and cutaneous lupus erythematosus (CLE) pathogeneses remains unknown. This review will compare advances in understanding the cause and pathogenesis of SLE and CLE. Recent findings Recently, mechanisms by which immune cell populations contribute to the pathogenesis of SLE and CLE have been queried. Studies have pointed to transitional B cells and B-cell activating factor (BAFF) signaling as potential drivers of SLE and CLE, with belimumab clinical data supporting these hypotheses. Ustekinumab trials and an exciting regulatory T cell (Treg) adoptive transfer in an SLE patient with cutaneous disease have suggested a role for T-cell-targeted therapies. The theory that neutrophil extracellular traps may be a source of autoantigens in SLE remains controversial, while neutrophils have been suggested as early drivers of cutaneous disease. Finally, plasmacytoid dendritic cells (pDCs) have been studied as a potential therapeutic target in SLE, and anti-blood DC antigen (anti-BDCA) antibody clinical trials have shown promise in treating cutaneous disease. Although recent findings have contributed to understanding SLE and CLE pathogenesis, the mechanistic link between these diseases remains an area requiring further research.
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