期刊
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
卷 127, 期 -, 页码 232-247出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.cmpb.2015.12.020
关键词
Left ventricle; Hemodynamics; Non-Newtonian; Shear rates; Computational fluid dynamics; Fluid-structure interaction
类别
资金
- Swinburne University of Technology
- National Heart Research Institute Singapore
- National Research Foundation Singapore [NMRC/EDG/1037/2011]
- Goh Cardiovascular Research Grant [Duke-NUS-GCR/2013/0009]
Recently, various non-invasive tools such as the magnetic resonance image (MRI), ultrasound imaging (USI), computed tomography (CT), and the computational fluid dynamics (CFD) have been widely utilized to enhance our current understanding of the physiological parameters that affect the initiation and the progression of the cardiovascular diseases (CVDs) associated with heart failure (HF). In particular, the hemodynamics of left ventricle (LV) has attracted the attention of the researchers due to its significant role in the heart functionality. In this study, CFD owing its capability of predicting detailed flow field was adopted to model the blood flow in images-based patient-specific LV over cardiac cycle. In most published studies, the blood is modeled as Newtonian that is not entirely accurate as the blood viscosity varies with the shear rate in non-linear manner. In this paper, we studied the effect of Newtonian assumption on the degree of accuracy of intraventricular hemodynamics. In doing so, various non-Newtonian models and Newtonian model are used in the analysis of the intraventricular flow and the viscosity of the blood. Initially, we used the cardiac MRI images to reconstruct the time-resolved geometry of the patient-specific LV. After the unstructured mesh generation, the simulations were conducted in the CFD commercial solver FLUENT to analyze the intraventricular hemodynamic parameters. The findings indicate that the Newtonian assumption cannot adequately simulate the flow dynamic within the LV over the cardiac cycle, which can be attributed to the pulsatile and recirculation nature of the flow and the low blood shear rate. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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