The neurobiology of innate and learned vocalizations in rodents and songbirds

Vocalizations are an important medium for sexual and social signaling in mammals and birds. In most mammals other than humans, vocalizations are specified by innate mechanisms and develop normally in the absence of auditory experience. By contrast, juvenile songbirds memorize and copy the songs of adult tutors, a process with many parallels to human speech learning. Despite the centrality of vocal learning to human speech, vocal production in humans as well as in songbirds exploits ancestral circuitry for innate vocalizations, and effective vocal communication depends on the fluent blending of innate and learned elements. This review covers recent advances in our understanding of central mechanisms for learned and innate vocalizations in birds and mice, including brainstem mechanisms that help to 'gate' vocalizations on or off, cortical involvement in learned and innate vocalizations, and the delineation of circuits that evaluate and reinforce song performance to facilitate vocal learning.