期刊
CURRENT OPINION IN NEUROBIOLOGY
卷 64, 期 -, 页码 89-95出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2020.03.014
关键词
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资金
- Direccion General de Asuntos del Personal Academico de la Universidad Nacional Autonoma de Mexico [PAPIIT-IA201819]
- NEI [R01EY011787]
- NINDS [R01NS110422]
- NIMH [R01MH115900]
- NSF [CRCNS 1822550]
Neuronal ensembles, i.e. coactive groups of neurons, have been long postulated to be functional building blocks of cortical circuits and units of the neural code. Calcium imaging of neuronal populations has demonstrated the widespread existence of spontaneous and sensory-evoked ensembles in cortical circuits in vivo. The development of two-photon optical techniques to simultaneously record and activate neurons with single cell resolution (piano experiments) has revealed the existence of pattern completion neurons, which can trigger an entire ensemble, and demonstrated a causal relation between ensembles and behavior. We review recent results controlling visual perception with targeted holographic manipulation of cortical ensembles by stimulating pattern completion neurons. Analyzing population activity as neuronal ensembles and exploiting pattern completion could enable control of brain states in health and disease.
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