期刊
CURRENT OPINION IN GENETICS & DEVELOPMENT
卷 64, 期 -, 页码 94-100出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2020.06.002
关键词
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资金
- DFG Research Center
- Cluster of Excellence - Center for Regenerative Therapies Dresden [DFG FZ 111, DFG EXC 168]
Cellular senescence has recently become causally implicated in pathological ageing. Hence, a great deal of research is currently dedicated towards developing senolytic agents to selectively kill senescent cells. However, senescence also plays important roles in a range of physiological processes including during organismal development, providing a barrier to tumorigenesis and in limiting fibrosis. Recent evidence also suggests a role for senescence in coordinating tissue remodelling and in the regeneration of complex structures. Through its non-cell-autonomous effects, a transient induction of senescence may create a permissive environment for remodelling or regeneration through promoting local proliferation, cell plasticity, tissue patterning, balancing growth, or indirectly through finely tuned interactions with infiltrating immune mediators. A careful analysis of the beneficial roles of cellular senescence may provide insights into important physiological processes as well as informing strategies to counteract its detrimental consequences in ageing and disease.
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