期刊
CURRENT OPINION IN CHEMICAL BIOLOGY
卷 58, 期 -, 页码 37-44出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2020.04.003
关键词
Native chemical ligation; Auxiliary-mediated ligation; Templated ligation; Traceless templated ligation; Chemical protein synthesis; Peptide ligation; Solid-phase peptide synthesis; Mirror-image proteins; Selenocysteine; Diselenide-selenoester ligation
资金
- University of Utah Graduate Research Fellowship
- NIH [AI150464, AI076168]
Native chemical ligation has enabled the chemical synthesis of proteins for a wide variety of applications (e.g., mirror-image proteins). However, inefficiencies of this chemoselective ligation in the context of large or otherwise challenging protein targets can limit the practical scope of chemical protein synthesis. In this review, we focus on recent developments aimed at enhancing and expanding native chemical ligation for challenging protein syntheses. Chemical auxiliaries, use of selenium chemistry, and templating all enable ligations at otherwise suboptimal junctions. The continuing development of these tools is making the chemical synthesis of large proteins increasingly accessible.
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