期刊
CURRENT OPINION IN CELL BIOLOGY
卷 66, 期 -, 页码 59-68出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2020.05.004
关键词
Morphogenesis; Force; Signaling; Actomyosin; Tension; Yap; Taz; Eph; Ephrin; PIEZO; Development
类别
资金
- National Institutes of Health/National Institute of Dental and Craniofacial Research (NIH/NIDCR) [F31DE028175]
- NIH/NIDCR [R01DE023337, R01DE025877, R00DE025874]
- National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI) [R01HL144785]
Morphogenesis is a physical process that requires the generation of mechanical forces to achieve dynamic changes in cell position, tissue shape, and size as well as biochemical signals to coordinate these events. Mechanical forces are also used by the embryo to transmit detailed information across space and detected by target cells, leading to downstream changes in cellular properties and behaviors. Indeed, forces provide signaling information of complementary quality that can both synergize and diversify the functional outputs of biochemical signaling. Here, we discuss recent findings that reveal how mechanical signaling and biochemical signaling are integrated during morphogenesis and the possible context-specific advantages conferred by the interactions between these signaling mechanisms.
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