期刊
CURRENT OPINION IN BIOTECHNOLOGY
卷 65, 期 -, 页码 171-179出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2020.02.016
关键词
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资金
- Synthetic Biology Initiative of the National University of Singapore [DPRT/943/09/14]
- Summit Research Program of the National University Health System [NUHSRO/2016/053/SRP/05]
- Ministry of Defence of Singapore (MINDEF) [RE2016-074]
- National Research Foundation of Singapore [NRF-NRFI05-2019-0004]
- US Air Force Office of Scientific Research - Asian Office of Aerospace Research and Development [FA2386-18-1-4058]
- US Office of the Secretary of Defense's Applied Research for the Advancement of Science and Technology Priorities program
Engineered probiotics are the next generation of live biotherapeutics that have been genetically modified to target specific diseases. With the advancements in synthetic biology, the engineering of probiotics has become increasingly sophisticated which has led to the development of therapies for treating cancer, infection, metabolic disorders and inflammation, as well as for diagnosing and preventing them. Herein, we review some of the recent examples of probiotics which have been engineered to target such diseases. Although there are numerous examples of engineered probiotics showing efficacy in animal models, there are no approved products on the market with very few in clinical trials. Therefore, we also discuss a set of features that may be incorporated into engineered probiotics to aid in clinical translation and ultimately, realizing the potential of these biotherapeutics.
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