期刊
CURRENT HYPERTENSION REPORTS
卷 22, 期 9, 页码 -出版社
SPRINGER
DOI: 10.1007/s11906-020-01071-z
关键词
Blood pressure; Hypertension; Age of hypertension onset; Hypertension heritability; Hypertension and cardiovascular disease; Clinical implications
资金
- University of Turku (UTU) including Turku University Hospital
- AarneKoskelo Foundation
- Finnish Foundation for Cardiovascular Research
- Finnish Medical Foundation
- Turku University Hospital
- Academy of Finland [321351]
- Paavo Nurmi Foundation
- Emil Aaltonen Foundation
- National Institute of Health [R01-HL134168, R01-HL131532, R01-HL143227, R01-HL142983]
Purpose of ReviewTo review the current evidence on research related to age of hypertension onset-its definition, correlates, heritability, and association with adverse outcomes. We also propose a framework for implementing assessment of hypertension onset age into clinical practice.Recent FindingsPrior studies have used both objective measurements and self-report to determine age of hypertension onset or early-onset hypertension. Yet, no criterion for standard definition currently exists for either. Data from epidemiological and clinical studies demonstrate that early-onset hypertension is a highly heritable trait that confers an increased risk for cardiovascular death and end-organ damage compared with late-onset hypertension.SummaryLiterature to date suggests that (parental) age of hypertension onset can be feasibly assessed for estimating (1) risk of future hypertension in non-hypertensive persons; and (2) the propensity for cardiovascular disease in individuals with established hypertension.
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