期刊
CURRENT DRUG TARGETS
卷 22, 期 6, 页码 609-630出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389450121999201013155202
关键词
Parkinson's Disease; Dopamine; Natural Products; Herbal Medicines; Natural Neuroprotective Agents; Neurodegeneration
资金
- National Key Research and Development Program of China [2016YFC1306605]
- National Natural Science Foundation of China [31670851]
Parkinson's disease is a common chronic disorder in adults with a complex pathogenesis and limited treatment options. Natural products for symptomatic treatment have shown neuroprotective effects by increasing dopamine levels, managing oxidative stress, and reducing inflammation.
Parkinson's disease is one of the most common adult-onset, a chronic disorder involving neurodegeneration, which progressively leads to deprivation of dopaminergic neurons in substantia nigra, causing a subsequent reduction of dopamine levels in the striatum resulting in tremor, myotonia, and dyskinesia. Genetics and environmental factors are believed to be responsible for the onset of Parkinson's disease. The exact pathogenesis of Parkinson's disease is quite complicated and the present anti-Parkinson's disease treatments appear to be clinically insufficient. Comprehensive researches have demonstrated the use of natural products such as ginseng, curcumin, ashwagandha, baicalein, etc. for the symptomatic treatment of this disease. The neuroprotective effects exhibited by these natural products are mainly due to their ability to increase dopamine levels in the striatum, manage oxidative stress, mitochondrial dysfunction, glutathione levels, clear the aggregation of alpha-synuclein, induce autophagy and decrease the pro-inflammatory cytokines and lipid peroxidation. This paper reviews various natural product studies conducted by scientists to establish the role of natural products (both metabolite extracts as well as pure metabolites) as adjunctive neuroprotective agents.
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