Alzheimer's Disease: Related Targets, Synthesis of Available Drugs, Bioactive Compounds Under Development and Promising Results Obtained from Multi-target Approaches

We describe herein the therapeutic targets involved in Alzheimer's disease as well as the available drugs and their synthetic routes. Bioactive compounds under development are also exploited to illustrate some recent research advances on the medicinal chemistry of Alzheimer's disease, including structure-activity relationships for some targets. The importance of multi-target approaches, including some examples from our research projects, guides new perspectives in search of more effective drug candidates. This review comprises the period between 2001 and early 2020.

Automated summary

This article summarizes the therapeutic targets, drugs, and synthetic routes involved in Alzheimer's disease, as well as some bioactive compounds under development to illustrate recent research advances in medicinal chemistry. The importance of multi-target approaches, including examples from research projects, is emphasized to guide the search for more effective drug candidates. This review covers the period between 2001 and early 2020.