期刊
CURRENT BIOLOGY
卷 31, 期 1, 页码 25-+出版社
CELL PRESS
DOI: 10.1016/j.cub.2020.09.074
关键词
-
资金
- European Research Council [694539]
- European Research Council (ERC) [694539] Funding Source: European Research Council (ERC)
The study demonstrates the important role of a pathway between ventral mossy cells and dorsal granule cells in the hippocampus in the formation of novelty-induced memory, influencing the activation of dorsal granule cells through excitatory transmission; furthermore, the manipulation of ventral mossy cell activity can bidirectionally regulate the acquisition of novelty-induced contextual memory.
Novelty facilitates memory formation and is detected by both the dorsal and ventral hippocampus. Although dentate granule cells (GCs) in the dorsal hippocampus are known to mediate the formation of novelty-induced contextual memories, the required pathways and mechanisms remain unclear. Here we demonstrate that a powerful excitatory pathway from mossy cells (MCs) in the ventral hippocampus to dorsal GCs is necessary and sufficient for driving dorsal GC activation in novel environment exploration. In vivo Ca2+ imaging in freely moving mice indicated that this pathway relays environmental novelty. Furthermore, manipulation of ventral MC activity bidirectionally regulates novelty-induced contextual memory acquisition. Our results show that ventral MC activity gates contextual memory formation through an intra-hippocampal interaction activated by environmental novelty.
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