期刊
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
卷 52, 期 4, 页码 697-711出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/10408347.2020.1823810
关键词
Vitamin D3; calcium carbonate; calcium citrate; calcium phosphate; multimineral
资金
- FundacAo de Amparo a Ciencia e Tecnologia de Pernambuco (FACEPE)
- CoordenacAo de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
Dietary supplements containing calcium salts and cholecalciferol may have inconsistent levels and deviate from label claims, requiring accurate analysis and detection. Analyzing these compounds is challenging due to the inorganic nature of calcium and the organic nature of cholecalciferol, necessitating specific pretreatment procedures and multiple analytical methods.
Dietary supplements composed by the combination of a calcium salt with cholecalciferol (vitamin D-3) are widely used for improving bone health in conditions caused by the deficiency of these compounds in the body. Historically, these supplements have been linked to quality and safety issues. In the case of calcium salts, the presence of potentially toxic contaminants such as lead (Pb) has already been alerted by health authorities from different countries. Meanwhile, cholecalciferol is very unstable under inadequate manufacturing and storage conditions. The content of both compounds in commercial dietary supplements is often found to be in disagreement with the label claims, which can lead to a deficient or excessive nutrient intake by consumers. In this scenario, analyzing these compounds is still a difficult and time-consuming task, which usually requires specific pretreatment procedures and multiple analytical methods due to the inorganic nature of calcium and the organic nature of cholecalciferol. Therefore, this article reviews the analytical methods, described in official compendia and scientific literature, for the determination of calcium salts and cholecalciferol in dietary supplement formulations. We also approached the sample preparation procedures highly required due to the matrix complexity of these materials.
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