期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 194, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.colsurfb.2020.111192
关键词
Oxygen-generating hydrogels; Smart materials; Tissue engineering; Calcium peroxide; Chondrocytes; Gelatin methacryloyl (GelMA)
资金
- National Council for Scientific and Technological Development (CNPq) [303752/2017-3, 404683/2018-5, 304133/2017-5, 424163/2016-0]
- Sweden-America Foundation (The Family Mix Entrepreneur Foundation)
- Olle Engkvist Byggmastare Foundation
- Serrapilheira Institute [Serra-1709-19479]
Cartilage is one of our body's tissues which are not repaired automatically by itself. Problems associated with cartilage are very common worldwide and are considered the leading cause of pain and disability. Smart biomaterial or Four dimensional (4D) biomaterials has started emerging as a suitable candidate, which are principally three dimensional (3D) materials that change their morphology or generate a response measured at space and time to physiologic stimuli. In this context, the release of oxygen through hydrogels in contact with water is considered as 4D biomaterials. The objective of this study is to develop strategies to release oxygen in a sustainable and prolonged manner through hydrogels systems to promote chondrocytes survival in oxygen-free environment. The 4D biomaterials are engineered from gelatin methacryloyl (GelMA) loaded with calcium peroxide (CPO), which have the ability to generate oxygen in a controlled and sustained manner for up to 6 days. The incorporation of CPO into the hydrogel system provided materials with enhanced mechanical and porosity properties. Furthermore, the hydrogels promoted chondrocyte survival and reduced cell death under oxygen-free conditions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据