期刊
CLINICAL RHEUMATOLOGY
卷 40, 期 3, 页码 999-1008出版社
SPRINGER LONDON LTD
DOI: 10.1007/s10067-020-05339-2
关键词
Cluster analysis; Cutaneous vasculitis; Cytokine; Dermatomyositis
类别
资金
- 13th Five-Year National Science and Technology Major Project for New Drugs of the Ministry of Science and Technology of China [2019ZX09734001-002-004]
- National Natural Science Foundation of China [81471615, 81601430]
- Medical and Health Science and Technology Innovation Project of Chinese Academy of Medical Sciences [2019-I2M-2-008]
The study identified multiple cytokine signatures in different subsets of patients with dermatomyositis, showing significant differences in levels of certain cytokines between active and stable disease groups. A combination of three specific cytokines demonstrated better performance in distinguishing between active and stable subsets. Additionally, a vasculitis-related subgroup was found in a specific subset based on cytokine profiles.
Objectives Dermatomyositis (DM) is a chronic inflammatory autoimmune disease with notable heterogeneity. The intent of this study was to explore the difference in cytokine profiles of different subsets in DM based on the disease activity and myositis-specific antibodies, and to identify the clinical phenotypes associated with different cytokine profiles. Methods Serum levels of 34 cytokines were prospectively measured in 47 consecutive DM patients and healthy controls. Concentrations of the cytokines were compared between the active and stable groups. Univariate and multivariate logistic regression models were used to identify the cytokines associated with DM disease activity. The cytokine profiles of anti-MDA5 and anti-TIF1 gamma subsets were compared, and the correlation analysis was performed between the elevated cytokines and clinical parameters in the two subsets. Hierarchical cluster analysis was used to establish clinical-cytokine subgroups in DM. Results Serum levels of MIP-1 alpha, IP-10, IL-8, IL-1RA, MCP-1, GRO-alpha, and IL-22 were significantly higher in DM patients compared with healthy controls. IP-10, IL-6, IL-1RA, IFN-alpha, and MCP-1 were significantly elevated in the DM-active subset than the DM-stable subset. The combination of three cytokines (IP-10, IL-1RA, and MCP-1) had a better performance in differentiating between the active subset and the stable subset than the conventional inflammatory markers. SDF-1 alpha, IP-10, IL-7, IL-17A, RANTES, IFN-gamma, TNF-alpha, MIP-1 beta, IFN-alpha, MCP-1, GRO-alpha, and IL-1 alpha were significantly higher in the anti-MDA5 subset than in the TIF1 gamma subset. Cluster analysis revealed a hypercytokinemic-vasculitis subgroup in patients with DM. Conclusions Multiple cytokine signatures were depicted in different subsets of DM. A vasculitis-associated subgroup was firstly identified in DM with regards of cytokinome and deserves further mechanistic study.
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