期刊
CLINICAL NUTRITION
卷 40, 期 4, 页码 2460-2463出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.clnu.2020.09.056
关键词
Carotenoids; Biomarkers; Magnetic resonance imaging; Medial temporal lobe; Prospective studies; Risk factors in epidemiology
资金
- Fondation pour la Recherche Medicale
- Caisse Nationale Maladie des Travailleurs Salaries
- Direction Generale de la Sante
- Mutuelle Generale de l'Education Nationale
- Institut de la Longevite
- Regional Government of Aquitaine
- Regional Government of Bourgogne
- Fondation de France
- Ministry of Research-INSERM Programme Cohortes et collections de donnees biologiques
- French National Research Agency [COGINUT ANR-06-PNRA-005, ANR 2007LVIE 003]
- Fondation Plan Alzheimer (FCS 2009-2012)
- Caisse Nationale pour la Solidarite et l'Autonomie (CNSA)
- Roche Pharma
- French National Research Agency (ANR) [17-EURE-0019]
This study found that an increase in plasma levels of total carotenoids and beta-carotene was associated with a smaller annual loss of medial temporal lobe volume, suggesting a potential beneficial role of carotenoids in preventing age-related neurodegeneration.
Background & aims: Carotenoids are vegetable pigments with neuroprotective properties. Clinical studies found efficacy of specific carotenoids on improving brain perfusion and functioning with aging. However, evidence of an effect on neurodegeneration, which may require longer follow-up period to observe, is more limited. Leveraging biomarkers from a large population-based cohort study of older adults, we investigated whether blood carotenoids were associated with atrophy of the medial temporal lobe (a biomarker of neurodegeneration in aging) over 10 years. Methods: This study included 461 dementia-free participants from the Three-City Bordeaux study (aged >65) who had plasma carotenoids measured at baseline and up to three repeated brain imaging exams in the subsequent 10 years. Results: In adjusted linear mixed models, each increase of 1 SD in plasma level of total carotenoids and of b-carotene was associated with 0.02 cm(3) (95% CI, 0.001-0.04; P = 0.04) and 0.02 cm(3) (95% CI, 0.01-0.04; P = 0.008) smaller medial temporal lobe volume loss per year, respectively. Conclusions: Our results based on a unique long-term prospective evaluation of a neuroimaging biomarker suggest a beneficial role of carotenoids for the prevention of age-related neurodegeneration. (C) 2020 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
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