期刊
CLINICAL INFECTIOUS DISEASES
卷 73, 期 11, 页码 E4073-E4081出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/ciaa1009
关键词
hydroxychloroquine; SARS-CoV-2; COVID-19; therapy; randomized controlled trial
资金
- crowdfunding campaign JoEmCorono
- Laboratorios Rubio
- Laboratorios Gebro Pharma
- Zurich Seguros
- SYNLAB Barcelona
- Generalitat de Catalunya
- Foundation Dorneur
A study conducted in Spain showed that early treatment with hydroxychloroquine did not bring more benefits than usual care for patients with mild COVID-19. The treatment did not reduce the risk of hospitalization or shorten the time to complete resolution of symptoms.
Background. No effective treatments for coronavirus disease 2019 (COVID-19) exist. We aimed to determine whether early treatment with hydroxychloroquine (HCQ) would be efficacious for outpatients with COVID-19. Methods. Multicenter open-label, randomized, controlled trial conducted in Catalonia, Spain, between 17 March and 26 May 2020. Patients recently diagnosed with <5-day of symptom onset were assigned to receive HCQ (800 mg on day 1 followed by 400 mg once daily for 6 days) or usual care. Outcomes were reduction of viral load in nasopharyngeal swabs up to 7 days after treatment start, disease progression up to 28 days, and time to complete resolution of symptoms. Adverse events were assessed up to 28 days. Results. A total of 293 patients were eligible for intention-to-treat analysis: 157 in the control arm and 136 in the intervention arm. The mean age was 41.6 years (SD, 12.6), mean viral load at baseline was 7.90 log 10 copies/mL (SD, 1.82), and median time from symptom onset to randomization was 3 days. No differences were found in the mean reduction of viral load at day 3 (-1.41 vs -1.41 log 10 copies/mL in the control and intervention arm, respectively) or at day 7 (-3.37 vs -3.44). Treatment did not reduce risk of hospitalization (7.1% control vs 5.9% intervention) nor shorten the time to complete resolution of symptoms (12 days, control vs 10 days, intervention). No relevant adverse events were reported. Conclusions. In patients with mild COVID-19, no benefit was observed with HCQ beyond the usual care.
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