4.7 Article

Epidemiological Trends of Racial Differences in Early- and Late-onset Group B Streptococcus Disease in Tennessee

期刊

CLINICAL INFECTIOUS DISEASES
卷 73, 期 11, 页码 E3634-E3640

出版社

OXFORD UNIV PRESS INC
DOI: 10.1093/cid/ciaa1511

关键词

group B Streptococcus; race; early-onset; late-onset

资金

  1. Emerging Infections Program's cooperative agreement from the Centers for Disease Control and Prevention [1U50CK000491]
  2. REDCap from the National Center for Advancing Translational Sciences/National Institutes of Health (NIH) [ULI TR000445]
  3. NIH [R01 HD090061, U01TR002398, R01AI134036]
  4. Career Development Award from the Office of Medical Research, Department of Veterans Affairs [IK2BX001701]
  5. March of Dimes
  6. Vanderbilt Institute for Clinical and Translational Research program - National Center for Research Resources [UL1 RR024975-01]
  7. National Center for Advancing Translational Sciences [2 UL1 TR000445-06]

向作者/读者索取更多资源

The study found racial disparities in rates of early-onset and late-onset GBS disease among infants, with black infants showing significant decreasing temporal trends in both EOGBS and LOGBS over the past decade in Tennessee. In contrast, there were no changes noted among white infants. Additional studies are needed to further characterize these disparities and identify factors influencing them.
Background. The rates of early-onset group B Streptococcus (GBS) disease (EOGBS) have declined since the implementation of universal screening and intrapartum antibiotic prophylaxis guidelines but late-onset (LOGBS) rates remain unchanged. Racial differences in GBS disease rates have been previously documented, with Black infants having higher rates of EOGBS and LOGBS, but it is not known if these have persisted. Therefore, we sought to determine the differences in EOGBS and LOGBS disease by race over the past decade in Tennessee. Methods. This study used active population-based and laboratory-based surveillance data for invasive GBS disease conducted through Active Bacterial Core surveillance in selected counties across Tennessee. We included infants younger than 90 days and who had invasive GBS disease between 2009 and 2018. Results. A total of 356 GBS cases were included, with 60% having LOGBS. EOGBS and LOGBS had decreasing temporal trends over the study period. Overall, there were no changes in temporal trend noted in the rates of EOGBS and LOGBS among White infants. However, Black infants had significantly decreasing EOGBS and LOGBS temporal trends (relative risk [95% confidence interval], .87 [.79, .96] [P = .007] and .90 [.84-.97] [P = .003], respectively). Conclusions. Years after the successful implementation of the universal screening guidelines, our data revealed an overall decrease in LOGBS rates, primarily driven by changes among Black infants. More studies are needed to characterize the racial disparities in GBS rates, and factors driving them. Prevention measures such as vaccination are needed to have a further impact on disease rates.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据