期刊
CLINICAL IMMUNOLOGY
卷 218, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2020.108513
关键词
Psoriasis; Psoriatic arthritis; IFN-gamma; IL-17A; Keratinocyte; Osteoclast
类别
资金
- National Natural Science Foundation of China [81972041]
- Beijing Natural Science Foundation [7172112]
- Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences [2019PT320006]
- National Institutes of Health/National Institute of Arthritis and Musculoskeletal and Skin Diseases [2R01AR062173]
- National Psoriasis Foundation Translational Research grant
Psoriasis is a common multifactorial autoimmune disease of the skin, and in a large percentage of patients, immune responses involve nail and joint pathology, which develop psoriatic arthritis (PsA). Historically, T helper 1 (Th1)-derived-IFN-gamma was abundantly detected in psoriatic skin and its correlation with development and severity of PsO, led to an early classification of psoriasis as a Th1-mediated disease. Investigations of the cellular and molecular mechanisms of PsO pathogenesis in recent years, together with impressive results of biologics against interleukin 17A (IL-17) have shifted focus on IL-17A. However, the contributions of IFN-gamma in IL-17 induced pathology and its involvement in the development of PsA have been largely overshadowed. This review summarizes the current knowledge on IFN-gamma and provides new insights on the contribution of IFN-gamma to PsO and PsA disease pathogenesis and development.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据