期刊
CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY
卷 14, 期 1, 页码 43-49出版社
KOREAN SOC OTORHINOLARYNGOL
DOI: 10.21053/ceo.2020.00416
关键词
Osteitis; Chronic Rhinosinusitis; Inflammation; Osteoblasts; Osteoclasts; Cytokine
资金
- National Research Foundation of Korea [2020R1A4A2002903]
- Education and Research Encouragement Fund of Seoul National University Hospital
- National Research Foundation of Korea [2020R1A4A2002903] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Chronic rhinosinusitis (CRS) is a multifactorial upper airway disease affecting about 12% of the general population, with evidence suggesting the impact of osteitis on its pathophysiology. Inflammation of the sinonasal mucosa plays a critical role in bone remodeling, with immune cells also believed to be involved.
Chronic rhinosinusitis (CRS) is a multifactorial and highly heterogeneous upper airway disease that affects approximately 12% of the general population. There is increasing evidence supporting the impact of osteitis on the pathophysiology of CRS. Osteitis is frequently observed in patients with CRS, and is associated with severe sinonasal inflammation and recalcitrant cases. The overlying inflammatory sinonasal mucosa plays a critical role in the initiation of osteitis; however, the underlying molecular mechanisms and functional significance remain unclear. Increasingly many studies have suggested that immune cells play a crucial role in the bone remodeling process in CRS. The purpose of this review is to summarize the current state of knowledge regarding the specific role of sinonasal inflammation in bone remodeling in CRS patients.
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