期刊
CLINICAL AND EXPERIMENTAL NEPHROLOGY
卷 24, 期 12, 页码 1122-1131出版社
SPRINGER
DOI: 10.1007/s10157-020-01961-1
关键词
IgA nephropathy; Intravenous administration; Streptococcus mutans; Dental caries; Rats; Glomerulonephritis
资金
- Japan Society for Promotion of Science [17K11959, 19K10098, 18H03010]
- Grants-in-Aid for Scientific Research [18H03010, 17K11959, 19K10098] Funding Source: KAKEN
Background IgA nephropathy (IgAN) is one of the most frequently occurring types of chronic glomerulonephritis. Previous analyses have revealed that a major pathogen of dental caries,Streptococcus mutans[which expresses collagen-binding protein (Cnm) on its surface], is involved in the pathogenesis of IgAN. Methods Cnm-positive S. mutans isolated from a patient with IgAN was intravenously administered to specific pathogen-free Sprague-Dawley rats to evaluate their kidney conditions. Results The urinary protein level of the S. mutans group reached a plateau at 30 days, with increased numbers of mesangial cells and an increased mesangial matrix. The numbers of rats with IgA-positive and/or C3-positive glomeruli were significantly greater in the S. mutans group than in the control group at 45 days (P < 0.05). Electron microscopy analyses revealed electron-dense depositions in the mesangial area among rats in the S. mutans group. There were significantly more CD68-positive cells (macrophages) in the glomeruli of the S. mutans group than in the glomeruli of the control group during the late phase (P < 0.05), similar to the findings in patients with IgAN. Conclusion Our results suggested that intravenous administration of Cnm-positive S. mutans caused transient induction of IgAN-like lesions in rats.
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