4.7 Article

Comparative Survival Analysis of Immunomodulatory Therapy for Coronavirus Disease 2019 Cytokine Storm

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The Longitudinal Immune Response to Coronavirus Disease 2019: Chasing the Cytokine Storm

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Summary: The progression of severe acute respiratory syndrome coronavirus 2 infection, COVID-19, to critical illness is associated with an exaggerated immune response, leading to a cytokine storm. This abnormal immune response includes delayed neutrophil recruitment, prolonged immune stimulation, and elevated levels of inflammatory markers. The dysfunctional immune response in COVID-19 also involves lymphopenia, reduced T cells, reduced natural killer cell maturation, and uncontrolled plasmablast proliferation causing aberrant IgG levels.

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