期刊
CHEMMEDCHEM
卷 15, 期 21, 页码 1974-1984出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cmdc.202000612
关键词
antiseptics; quaternary ammonium compounds; quaternary phosphonium compounds; trivalent sulfonium compounds; qacA; QacR
资金
- National Institute of General Medical Sciences [R35 GM119426]
- National Institute of Allergy and Infectious Diseases of the National Institutes of Health [T32AI106699]
The prevalence of quaternary ammonium compounds (QACs) as common disinfecting agents for the past century has led bacteria to develop resistance to such compounds. Given the alarming increase in resistant strains, new strategies are required to combat this rise in resistance. Recent efforts to probe and combat bacterial resistance have focused on studies of multiQACs. Relatively unexplored, however, have been changes to the primary atom bearing positive charge in these antiseptics. Here we review the current state of the field of both phosphonium and sulfonium amphiphilic antiseptics, both of which hold promise as novel means to address bacterial resistance.
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