期刊
CHEMISTRY-AN ASIAN JOURNAL
卷 15, 期 23, 页码 4070-4076出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.202000954
关键词
Metal-Catalysis; Spiroannulation; Stereoselectivity; Fluoromethylfunctionaliztion; (Z)-Spiroindenes
资金
- NSFC [21871112]
Two classes of new catalytic spiroannulation-fluormethylfunctionaliztions ofpara-quinone methide (p-QM)-containing 1,5-enynes have been established under redox-neutral conditions. Palladium-catalyzed spiroannulation-iododifluoromethylation with ethyl difluoroiodoacetate oriented completely stereoselective access to (Z)-spiroindenes and the latter included copper-catalyzed three-component spiroannulation-cyanotrifluoromethylation starting from Togni's reagent and trimethylsilanecarbonitrile (TMSCN). Both reaction pathways involve fluoroalkyl radical-triggered 1,6-addition/5-exo-digannulation/metal radical cross-coupling/reductive elimination sequence, providing practical and stereoselective protocols for rapidly constructing cyclohexadienone-containing spiroindenes with generally good yields.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据