期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 27, 期 19, 页码 5936-5943出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202003996
关键词
macrocyclization; stereoselective aza aldol reaction; structure– activity relationships; total synthesis; zampanolide
资金
- Swiss National Science Foundation [200021_149253, 200020_175744]
- Ministerio de Ciencia e Innovacion [PID2019-104545RB-I00]
- Fondo de Investigaciones Sanitarias [COV20/01007, H2020-MSCA-ITN-2019 860070 TUBINTRAIN]
- Swiss National Science Foundation (SNF) [200020_175744, 200021_149253] Funding Source: Swiss National Science Foundation (SNF)
The study describes the convergent synthesis of analogues of the marine macrolide (-)-zampanolide, incorporating an embedded N-substituted morpholine moiety. Among the three investigated morpholino-zampanolides, the N-acetyl and N-benzoyl derivatives both showed nanomolar antiproliferative activity, while the N-tosyl derivative had significantly reduced activity.
We describe the convergent synthesis of three prototypical examples of a new class of analogues of the complex, cytotoxic marine macrolide (-)-zampanolide that incorporate an embedded N-substituted morpholine moiety in place of the natural tetrahydropyran ring. The final construction of the macrolactone core was based on a high-yielding intramolecular HWE olefination, while the hemiaminal-linked side chain was elaborated through a stereoselective, BINAL-H-mediated addition of (Z,E)-sorbamide to a macrocyclic aldehyde precursor. The synthesis of the common functionalized morpholine building block involved two consecutive epoxide openings with tosylamide and the product of the first opening reaction, respectively, as nucleophiles. Of the three morpholino-zampanolides investigated, the N-acetyl and the N-benzoyl derivatives both exhibited nanomolar antiproliferative activity, thus being essentially equipotent with the natural product. In contrast, the activity of the N-tosyl derivative was significantly reduced.
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