期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 26, 期 65, 页码 14861-14865出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202003562
关键词
(hetero)aromatic amine; ammonia; hydroamination; medicinal chemistry toolkit; photoredox
资金
- EPSRC [EP/P016618/1, EP/N025652/1]
- EPSRC [EP/N025652/1, EP/P016618/1] Funding Source: UKRI
3-Amino-substituted saturated nitrogen heterocycles are an important subclass of beta-diamines, appearing in a number of clinical agents. Herein, we report a unified approach to these products based upon the regioselective photoredox-mediated hydroamination of enecarbamates. The amine coupling partner can encompass diverse amine types under a single set of reaction conditions, including primary alkyl amines, ammonia, aryl and heteroaryl amines, and N-H heterocycles. The method enables the synthesis of a wide range of pharmaceutically relevant building blocks.
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