期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 27, 期 15, 页码 4789-4816出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202003927
关键词
aqueous catalysis; biocatalysis; biological chemistry; cellular chemistry; organometallic catalysis
资金
- Spanish grants [SAF2016-76689-R, CTQ2017-84767-P, CTQ2016-81797-REDC]
- Conselleria de Cultura, Educacion e Ordenacion Universitaria [2015-CP082, ED431C-2017/19, ED431G 2019/03]
- European Union (European Regional Development Fund-ERDF)
- European Research Council [340055]
- Xunta de Galicia [ED481B-2019-005]
Developing non-natural biocompatible transformations in biologically relevant media has attracted significant interest in the past decade, with the use of transition metal complexes offering unique possibilities. This translation of metal catalyst potential to biological environments poses challenges, but describing the most relevant advances and key challenges helps identify issues from an organometallic perspective.
During the last decade, there has been a tremendous interest for developing non-natural biocompatible transformations in biologically relevant media. Among the different encountered strategies, the use of transition metal complexes offers unique possibilities due to their high transformative power. However, translating the potential of metal catalysts to biological settings, including living cells or small-animal models such as mice or zebrafish, poses numerous challenges associated to their biocompatibility, and their stability and reactivity in crowded aqueous environments. Herein, we describe the most relevant advances in this direction, with a particular emphasis on the systems' structure, their mode of action and the mechanistic bases of each transformation. Thus, the key challenges from an organometallic perspective might be more easily identified.
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