Stereoselective Copper-Catalyzed Direct Aldol Reaction of β, γ-Unsaturated α-Ketoesters with Coumaran-3-Ones

An efficient direct aldol reaction between coumaran-3-ones and beta, gamma-unsaturated alpha-ketoesters by virtue of a chiral copper complex is developed. A series of coumaran-3-one derivatives containing chiral tertiary alcohol structures are obtained in excellent yields and stereoselectivities.

Automated summary

An efficient direct aldol reaction using a chiral copper complex was developed for the synthesis of chiral tertiary alcohol-containing coumaran-3-one derivatives with excellent yields and stereoselectivities.